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Combining Epigenetic and Immunotherapy to Combat Cancer
The
most exciting recent advance for achieving durable management of
advanced human cancers is immunotherapy, especially the concept of
immune checkpoint blockade. However, with the exception of melanoma,
most patients do not respond to immunotherapy alone. A growing body of
work has shown that epigenetic drugs, specifically DNA methyltransferase
inhibitors, can upregulate immune signaling in epithelial cancer cells
through demethylation of endogenous retroviruses and cancer testis
antigens. These demethylating agents may induce T-cell attraction and
enhance immune checkpoint inhibitor efficacy in mouse models.
- cancerres.aacrjournals.org
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Heal: The Vital Role of Dogs in the Search for Cancer Cures
Heal: The Vital Role of Dogs in the Search for Cancer Cures
Arlene Weintraub's book explores a topic in cancer not often
discussed: the drug development process and its effects on both people
and dogs.
What do dogs have to do with cancer research? “Heal,” which
chronicles one woman’s research journey across the United States,
explains that dogs get some of the same cancers as people, and, in
veterinary clinical trials, have been among the first to try new types
of medications that were eventually approved for both dogs and humans.
- curetoday.com
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More Reflections on the SeaWorld Agreement
Today,
SeaWorld CEO Joel Manby and I sent a letter to President Obama urging
him to use a wide range of diplomatic tools to pressure Japan to end its
commercial whaling activities and to stop contravening international
law by slaughtering hundreds of innocent whales. Manby has assured me
that this is just a first indicator of SeaWorld's new commitment to
advocacy on marine animal protection efforts, and that the company will
join with anti-whaling advocates to finish off the era of commercial
whaling on our planet.
- huffingtonpost.com
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ABOUT VETERINARY ONCOLOGY SERVICES
Veterinary
Oncology Services is the only center involved in advanced cancer
treatment with DNA cancer treatment vaccines and Electrochemotherapy
(targeting the cancer and offering a significant advantage in reducing
drug dosages and not harming healthy tissue). We routinely see clients
from all over New York state and from as far away as Canada and Florida.
Dr. Impellizeri is also a Visiting Scholar at Vassar College in
Poughkeepsie, NY in the Department of Biology.
We can be reached at:
Phone: 845 205 2768
Email: info@petcancerinformation.com
Please call us to refer a patient or visit us on our website at www.petcancerinformation.com
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IN THE NEWS
Cali's Cancer is gone!
Vets warn pet owners over debilitating Lyme disease as they reveal staggering 560% rise in 6 years
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Cat Survives 8 Days In Box After Owner Accidentally Mails Her Across England
Cupcake is an incredibly lucky cat.
The Siamese survived being stuck inside a small box for eight days after her owner accidentally put her in the post.
Julie Bagott didn’t spot her pet snoozing inside the parcel as she
packed it with DVDs at her home in Falmouth, in southwest England. Then
she dropped the box in the mail.
After traveling for 260 miles, Cupcake arrived in Worthing, West Sussex, on the other side of the country.
Grove Lodge Veterinary Group on Thursday
The package’s recipients were stunned to open the box and find the cute cat curled up alongside the movies they’d bought.
- huffingtonpost.com
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Protecting your pet from Rabies
KNOXVILLE,
Tenn. (WVLT) -- Rabies is an easily preventable disease but Tennessee
has seen at least 4 confirmed cases in dogs since January of this year.
In the United States one to two people die annually from rabies but it
kills more than 55,000 people worldwide each year. In 2012, there were
6,000 reported cases of animal rabies in the United States alone.
Rabies is a deadly virus that attacks the nervous system. The virus
is spread through saliva and is usually transmitted to people and
animals by a bite from an infected animal.
- local8now.com
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Vietnam veteran struggling with PTSD saved by death row dog — Pets For Patriots Blog
Ed
is a Vietnam veteran and former Army Sergeant. After decades of coping
with PTSD (Post Traumatic Stress Disorder) and at the encouragement of
his wife, he saved – and is saved by – an adult dog on death row. Thanks
to our partnership with Macomb County Animal Shelter for helping us
make Ed’s story possible; this is his letter to us.
I am retired. In 1967-69, I was in the US Army, and did a year in
Viet Nam as a recon scout. My year there gave me a lifetime full of bad
memories and the stuff that nightmares are made of.
- blog.petsforpatriots.org
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Giorgio Armani Goes Fur-Free
Good news for cuddly animals and the people who love them!
Luxury clothing designer Giorgio Armani announced today that his
labels will be 100 percent fur-free, starting with the autumn/winter
2016 collections.
The brand pledged to go fur-free after working with the Humane
Society of the U.S. and the Fur Free Alliance, a coalition of 40 animal
protection organizations in 28 countries working to end the fur trade.
“I am pleased to announce that the Armani Group has made a firm
commitment to abolish the use of animal fur in its collections,” the
Italian designer said in a statement released by the HSUS.
- huffingtonpost.com
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Processed Pet Food — Biologically Inappropriate for Your Pet
Not
long ago I ran across a headline in a pet food industry journal that
gave me a chuckle. It read, "More Americans consider raw pet diets amid
safety issues: Sales of raw pet food have increased sharply".1 I'm
smiling because it seems the best efforts of the U.S. Federal Drug
Administration (FDA), the American Veterinary Medical Association
(AVMA), the American Animal Hospital Association (AAHA), many
board-certified veterinary nutritionists, and a variety of other pet
food industry organizations and individual special interest groups to
scare people away from raw pet diets aren't having the intended effect.
- healthypets.mercola.com
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